The role of airway inflammation and bronchial hyperresponsiveness in athlete`s asthma
Purpose Asthma is frequently reported in endurance athletes. The aim of the present study was to assess the long-term airway inflammatory response to endurance exercise in high-level athletes with and without asthma.
Methods In a cross-sectional design, 20 asthmatic athletes (10 swimmers and 10 cross-country skiers), 19 athletes without asthma (10 swimmers and 9 cross-country skiers), and 24 healthy nonathletes completed methacholine bronchial challenge, lung function tests, and sputum induction on two separate days. All athletes competed on a national or international level and exercised =10 h·wk-1. The nonathletes exercised =5 h/wk and reported no previous lung disease. Bronchial hyperresponsiveness (BHR) was defined as a methacholine provocation dose causing 20% decrease in the forced expiratory volume in 1 s of =8 µmol.
Results BHR was present in 13 asthmatic athletes (62%), 11 healthy athletes (58%), and 8 healthy nonathletes (32%), and the prevalence differed among groups (P = 0.005). Sputum inflammatory and epithelial cell counts did not differ between groups and were within the normal range. Median (25th to 75th percentiles) sputum interleukin-8 was elevated in both asthmatic (378.4 [167.0-1123.4]) and healthy (340.2 [175.5-892.4]) athletes as compared with healthy nonathletes (216.6 [129.5-314.0], P = 0.02). No correlations were found between provocation dose causing 20% decrease and sputum cell counts.
Conclusion Independent of asthma diagnosis, a high occurrence of BHR and an increased sputum interleukin-8 were found in athletes as compared with nonathletes. Airway inflammation or epithelial damage was not related to BHR.
© Copyright 2018 Medicine & Science in Sports & Exercise. Lippincott Williams & Wilkins. Kaikki oikeudet pidätetään.
Aiheet: | urheilulääketiede hengitys keuhkot häiriö sairaus murtomaahiihto uinti |
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Aihealueet: | biologiset ja lääketieteelliset tieteet kestävyys urheilu |
Tagging: | Asthma |
DOI: | 10.1249/MSS.0000000000001478 |
Julkaisussa: | Medicine & Science in Sports & Exercise |
Julkaistu: |
2018
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Vuosikerta: | 50 |
Numero: | 4 |
Sivuja: | 659-666 |
Julkaisutyypit: | artikkeli |
Kieli: | englanti (kieli) |
Taso: | kehittynyt |