SUMMARY Aim. The aim of the present study was to investigate possible changes in the plasma pro-inflammatory cytokines levels in response to an intensified training during preparatory period for the new season (preseason, December), and relation to reactive oxygen and nitrogen species (RONS) and body composition in highly trained athletes. Methods. Forty-one athletes and twenty untrained males participated in the study. Results. Plasma hydroperoxide (H2O2) and nitric oxide (NO) were elevated 2-fold in judoists and wrestlers whereas lipid peroxides (LPO) and protein carbonyls (PC) were on the same or even lower level compared to non-athletes. H2O2 significantly correlated with cytokines IL-1? and TNF? which reached the highest level in wrestlers. Free fat mass (FFM) was higher in athletes than non-athletes, and correlated with creatine kinase (r=0.619), IL-1? (r=0.610, P<0.001) and TNF? (r=0.555, P<0.001). Oppositely, fat mass (FM) was markedly lower in athletes but not correlated with any inflammatory mediators. Conclusion. The results show that physical training is typical of combat sports stimulates the generation of signal molecules H2O2 and NO as well as improves the cytokine response is associated with body composition in highly trained athletes.
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