Quercetin reduces illness but not immune perturbations after intensive exercise
Purpose: To investigate the effects of quercetin supplementation on incidence of upper respiratory tract infections (URTI) and exercise-induced changes in immune function.
Methods: Trained male cyclists (N = 40) were randomized to quercetin (N = 20) or placebo (N = 20) groups and, under double-blind procedures, received 3 wk quercetin (1000 mg[middle dot]d-1) or placebo before, during, and for 2 wk after a 3-d period in which subjects cycled for 3 h[middle dot]d-1 at approximately 57% Wmax. Blood and saliva samples were collected before and after each of the three exercise sessions and assayed for natural killer cell activity (NKCA), PHA-stimulated lymphocyte proliferation (PHA-LP), polymorphonuclear oxidative-burst activity (POBA), and salivary IgA output (sIgA).
Results: Pre- to postexercise changes in NKCA, PHA-LP, POBA, and sIgA did not differ significantly between quercetin and placebo groups. URTI incidence during the 2-wk postexercise period differed significantly between groups (quercetin = 1/20 vs placebo = 9/20, Kaplan-Meier analysis statistic = 8.31, P = 0.004).
Conclusion: Quercetin versus placebo ingestion did not alter exercise-induced changes in several measures of immune function, but it significantly reduced URTI incidence in cyclists during the 2-wk period after intensified exercise.
© Copyright 2007 Medicine & Science in Sports & Exercise. Lippincott Williams & Wilkins. Kaikki oikeudet pidätetään.
Aiheet: | immuniteetti tartunta kuormitus sairaus hengitys pyöräily lisäravinteiden käyttö antioksidantti |
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Aihealueet: | kestävyys urheilu biologiset ja lääketieteelliset tieteet |
DOI: | 10.1249/mss.0b013e318076b566 |
Julkaisussa: | Medicine & Science in Sports & Exercise |
Julkaistu: |
2007
|
Vuosikerta: | 39 |
Numero: | 9 |
Sivuja: | 1561-1569 |
Julkaisutyypit: | artikkeli |
Kieli: | englanti (kieli) |
Taso: | kehittynyt |