Tramadol is a synthetic opioid widely used for the management of pain in sport setting. Tramadol is considered an effective substance to reduce acute and chronic pain because it acts by binding to the µ-opioid receptor to induce analgesia and sedation. However, tramadol also inhibits serotonin and norepinephrine reuptake and thus, it might play a role in the regulation of mood. In the past years, tramadol has caught attention of media and antidoping authorities because this substance might be the subject of abuse in some sports, notably cycling.
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