The aim of this study was to analyze the rating perceived exertion and physical performance changes after one session of circuit training in hypoxia (FiO2= 0.16) or normoxia (FiO2= 0.21). Eleven resistance-trained young male subjects participated in the study. They performed two circuit training session (hypoxia or normoxia) in randomized order. Three days before the first training session, a familiarization and 6RM test session was performed. After 72 hours of rest, the subjects performed the last training session. The circuit training consisted of two blocks of three exercises (Block 1: bench press, deadlift and elbow flexion; Block 2: half-squat, triceps extension, and ankle extension). Each exercise was performed at 6RM. Rest periods lasted for 35 s between exercises, 3 min between sets, and 5 min between blocks. Rating of perceived exertion (RPE) and peak and mean force, velocity, power and acceleration and time to perform peak power and velocity were determined during all the sets half-squat and bench press exercises. No differences were observed in RPE values between hypoxia and normoxia. Moreover, significant differences were observed in the first trial of half squat in peak acceleration (normoxia = 2.9 ± 0.7 m/s2; hypoxia = 2.2 ± 1.1 m/s2; p = 0.037) and peak power (normoxia = 1577.1 ± 587.5 W; hypoxia = 1227.2 ± 636.3 W; p = 0.039) between hypoxia and normoxia. In conclusion, these results indicate that simulated hypoxia during circuit training exercise decreases peak power and peak acceleration but maintains rating perceived exertion of the exercise. These differences must be taken into account to avoid an excessive fatigue
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